预览加载中，请您耐心等待几秒...
1/10
2/10
3/10
4/10
5/10
6/10
7/10
8/10
9/10
10/10
亲，该文档总共45页，到这已经超出免费预览范围，如果喜欢就直接下载吧～
如果您无法下载资料，请参考说明：
1、部分资料下载需要金币，请确保您的账户上有足够的金币
2、已购买过的文档，再次下载不重复扣费
3、资料包下载后请先用软件解压，在使用对应软件打开
FudanGeneticWorkshop2005GeneticEpidemiologyinPopulationsFudanGeneticWorkshop,Jan042005LearningObjectivesforThisLectureGeneticAssociationStudiesinEpidemiologyGeneticAssociationStudiesinEpidemiologyLearningObjectivesforThisLectureDirectmethodTestingwhetheraparticularalleleisadisease-predisposing(causative)allele‘exposurestatus’directlymeasured2.‘LDMapping’(indirectmethod)‘exposurestatus’notdirectlymeasuredRelyonmarkerscorrelatedwithtrueexposurestatusThiscorrelationisduetolinkagedisequilibriumDirectTestsIndirectTestsDirectMethod:CandidateAlleleTestingIndirectMethod:LDGeneMappingIndirectAssociationStudiesinEpidemiologyLocalizationIndirectAssociationStudiesinEpidemiologySource:Uhletal,2001.AJHG69:1290-1300.IndirectAssociationStudiesinEpidemiologyCandidategeneLDstudiesCandidategeneLDstudiesCandidategeneLDstudiesGenotype-leveltestsfordiseaseassociationEx:Alzheimer’sdiseaseandAPOESNPs…ModelingissuesModelingissuesLogisticregressionIndirectAssociationStudiesinEpidemiologyEx:TGFaandoralcleftsEx:TGFaandoralcleftsEx:IncorporationofEnvironmentEx:IncorporationofEnvironmentLogisticregressionwithinteractionInterpretationsofIndirectAssociationStudiesLearningObjectivesforThisLectureChoiceofDesignandAnalysisChoiceofDesignandAnalysisStudyDesignsforLDMappingStrategiesContrastsbetweenepidemiologicandfamily-basedassociationdesignsDesignsforLDstudiesofunrelatedindividualsStudyDesignsusedforLDmappingStudyDesignsusedforLDmappingCase-ControlStudyDesignsusedforLDmapping1)AdjustmentinAnalysisAssessandcorrectforpossiblestratificationGenomiccontrol(DevlinandRoeder,1999,GenomicControlforassociationstudies.Biometrics,1999.55:p.997-1004)Clusteranalysisofgeneticsubstructurebasedonmarkers(STRUCTURE,Pritchardetal.Inferenceofpopulationstructureusingmultilocusgenotypedata.Genetics,2000.155(2):p.945-59)FSTEx:UseFsttodetectgrossgeneticdistancesbetweencasesandcontrolsasindicationofsubstructureSolutionstoPopulationStratificationProblem:HowtodistinguishLDfromallelicassociationsduetosub-structu
